• A bottle of True Botanicals Microbiome Enzyme Essence in a dark amber glass container with a black screw cap is displayed against a white background. Behind the bottle, two smooth droplets of golden, translucent liquid are spread, highlighting its lightweight and hydrating formula. The label emphasizes its placement in the "renew" collection.
  • Microbiome Enzyme Essence
  • Microbiome Enzyme Essence benefits highlighted on a soft bubbly background.
  • An image displaying "90% said their skin looks dewy after applying the product*" with before and after close-ups of the forehead, highlighting improvements after 4 weeks. A Microbiome Enzyme Essence bottle is featured alongside clinical study details.
  • 90% of participants said, "My skin feels baby soft." 93% reported, "My skin is healthier-looking." 90% said, "My skin looks dewy after using this product." *Based on a 28-day clinical study of 52 women aged 35-70 using the product twice daily.
  • An image showing "93% said their skin is healthier-looking*" with before and after close-ups of skin improvement after 4 weeks. A Microbiome Enzyme Essence bottle is featured, with study details below.
  • Pineapple and papaya enzymes help soften and exfoliate by shedding dead skin cells from the surface. Wild-sourced finger lime breaks down dead skin cells to enhance absorption of other products, while buckwheat ferment, a fermented prebiotic, helps balance and nourish the skin's microbiome.
  • Microbiome Enzyme Essence
  • A bottle of True Botanicals Microbiome Enzyme Essence in a dark amber glass container with a black screw cap is displayed against a white background. Behind the bottle, two smooth droplets of golden, translucent liquid are spread, highlighting its lightweight and hydrating formula. The label emphasizes its placement in the "renew" collection.
  • Microbiome Enzyme Essence
  • Microbiome Enzyme Essence benefits highlighted on a soft bubbly background.
  • An image displaying "90% said their skin looks dewy after applying the product*" with before and after close-ups of the forehead, highlighting improvements after 4 weeks. A Microbiome Enzyme Essence bottle is featured alongside clinical study details.
  • 90% of participants said, "My skin feels baby soft." 93% reported, "My skin is healthier-looking." 90% said, "My skin looks dewy after using this product." *Based on a 28-day clinical study of 52 women aged 35-70 using the product twice daily.
  • An image showing "93% said their skin is healthier-looking*" with before and after close-ups of skin improvement after 4 weeks. A Microbiome Enzyme Essence bottle is featured, with study details below.
  • Pineapple and papaya enzymes help soften and exfoliate by shedding dead skin cells from the surface. Wild-sourced finger lime breaks down dead skin cells to enhance absorption of other products, while buckwheat ferment, a fermented prebiotic, helps balance and nourish the skin's microbiome.
  • Microbiome Enzyme Essence

Microbiome Enzyme Essence

$82

Our next-generation prebiotic essence is clinically proven to deliver plump, dewy looking skin. It's like gut health, but for your skin!

Full Size (4oz | 118mL)
TRUE BEAUTIES™ MEMBERSHIP BENEFITS
Membership includes:
  • Exclusive Member Savings
  • Free Skincare Gifts
  • Early Access to Sales
  • Cancel Online Anytime
Frequency Recommendation
We recommend the following replenishment cycle:
  • Usage
  • Frequency
  • Twice a day
  • Every 2 months
  • Once a day
  • Every 3 months
  • Just a few times a week
  • Every 4 months
Free Shipping over $35 
Try risk-free for 30 days or your money back

What It Is

This clinically proven essence floods the skin with the highest quality hydrating botanicals and active prebiotics that nourish your skin’s good bacteria to reveal baby soft, dewy and illuminated skin every single day. A healthy skin microbiome helps strengthen your skin barrier, protect skin from irritants and inflammation, and helps to improve your skin’s nutrient absorption. Our Microbiome Enzyme Essence delivers on those benefits while also providing resurfacing benefits with nature’s most gentle yet effective AHAs and enzymes like wild-sourced Finger Lime and biocompatible Papaya & Pineapple. Use this essence to prep your skin for the next steps in your routine all while you strengthen & protect it, too. Winner of the 2023 SELF Healthy Beauty Award for Best Essence.

Key Ingredients
  • pineapple ingredient

    Pineapple & Papaya Enzyme

  • fingerlime ingredient

    Wild-Sourced Finger Lime

  • buckweed ingredient

    Buckwheat Ferment

    Full Ingredients List

    camellia sinensis (green tea) leaf extract*, zingiber officinale (ginger) water*, aloe barbadensis leaf juice*, glycerin, maltodextrin, phenethyl alcohol, bromelain, papain, xanthan gum, ethylhexylglycerin, citrus australasica (finger lime) fruit extract, davidsonia jerseyana (davidson plum) fruit extract, sodium hyaluronate, sodium phytate, citric acid, water/aqua/eau, sodium benzoate, potassium sorbate.

    *organic

    Other Products You’ll Love

    • Bestseller
      100%
      saw a reduction in the look of fine lines and wrinkles
      Renew Pure Radiance Oil

      Renew Pure Radiance Oil

      Renew Pure Radiance Oil

      Our best-selling face oil that helps target signs of aging and is clinically proven to outperform a leading anti-aging moisturizer.
    • Bestseller
      100%
      saw softer and smoother skin after 1 week
      True Botanicals Chebula Active Serum bottle shown with serum swirls in the background. Surrounding the product are four award and certification badges: "Shop TODAY Editors’ Pick 2025," "MADE SAFE Ingredient Integrity Award 2023," and "National Eczema Association Accepted" seal — highlighting the product’s clean, effective, and sensitive-skin-approved formulation.

      Chebula Active Serum

      Chebula Active Serum

      This serum is clinically proven to outperform two leading anti-aging serums in fighting fine lines and wrinkles.
    • Bestseller
      100%
      saw a highly significant improvement in skin hydration
      True Botanicals Phyto-Retinol Advanced Clinical Cream jar with award badges, displayed on a swipe of creamy product texture.

      Phyto-Retinol Advanced Clinical Cream

      Phyto-Retinol Advanced Clinical Cream

      10 age-defying benefits in 1 cream. A retinol alternative for radiant, plump skin.
    • Selling Fast
      112%
      increase in hydration around the eye area
      True Botanicals Resurrection Radiance Eye Cream is a deeply nourishing formula designed to target fine lines, dark circles, and dryness. Infused with potent plant-based ingredients, this luxurious eye cream hydrates, brightens, and smooths the delicate under-eye area. Its rich texture absorbs quickly, delivering lasting moisture and a visibly firmer appearance. Perfect for daily use, it restores radiance while supporting the skin barrier for a refreshed, youthful look.

      Resurrection Radiance Eye Cream

      Resurrection Radiance Eye Cream

      Clinically proven to dramatically reduce the appearance of dark circles, puffiness and wrinkles around the eyes.

      FAQs

      Can I use this with Clear Toner?

      Yes! After applying Clear Toner, you can apply our Microbiome Enzyme Essence. The two of them work better together!

      Is this good for all skin types?

      Yes, all skin types can benefit from the Microbiome Enzyme Essence, especially dry skin types. It’s also great for sensitive skin types!

      Is this product safe to use during pregnancy?

      Yes! Our Microbiome Enzyme Essence is MADE SAFE® Certified, which ensures it is free from over 15,000 known toxins and has undergone further rigorous testing to ensure it does not contain any ingredients known to or suspected of harming pregnant individuals. If you are pregnant or breastfeeding, we always recommend consulting with your doctor before introducing any new skincare products into your routine. Everyone's skin and situation is different, so we cannot take into account your unique needs that may contribute to differentiated standards during your pregnancy or postpartum period. For more information, check the MADE SAFE® Healthy Pregnancy Guide. 

      How long will the Microbiome Enzyme Essence last?

      Each bottle contains approximately 236 uses. When used twice daily, it will last about 118 days. If used once a day, it will last double the time - 236 days. Your usage may vary depending on how much you apply.

      Pure. Potent. Proven.®

      Pure. Potent. Proven.®

      Luxurious, aromatherapeutic products formulated with the purest, functional plant actives that fill your skin's nutrient gaps, support your skin's microbiome, and deliver clinically proven results. This is a better path to anti-aging.

      Luxurious, aromatherapeutic products formulated with the purest, functional plant actives that fill your skin's nutrient gaps, support your skin's microbiome, and deliver clinically proven results. This is a better path to anti-aging.

      Made Safe logo
      PETA Approved logo
      EWG Verified
      Microbiome Friendly
      Learn More