• A bottle of True Botanicals Microbiome Enzyme Essence in a dark amber glass container with a black screw cap is displayed against a white background. Behind the bottle, two smooth droplets of golden, translucent liquid are spread, highlighting its lightweight and hydrating formula. The label emphasizes its placement in the "renew" collection.
  • Microbiome Enzyme Essence
  • Microbiome Enzyme Essence benefits highlighted on a soft bubbly background.
  • An image displaying "90% said their skin looks dewy after applying the product*" with before and after close-ups of the forehead, highlighting improvements after 4 weeks. A Microbiome Enzyme Essence bottle is featured alongside clinical study details.
  • 90% of participants said, "My skin feels baby soft." 93% reported, "My skin is healthier-looking." 90% said, "My skin looks dewy after using this product." *Based on a 28-day clinical study of 52 women aged 35-70 using the product twice daily.
  • An image showing "93% said their skin is healthier-looking*" with before and after close-ups of skin improvement after 4 weeks. A Microbiome Enzyme Essence bottle is featured, with study details below.
  • Pineapple and papaya enzymes help soften and exfoliate by shedding dead skin cells from the surface. Wild-sourced finger lime breaks down dead skin cells to enhance absorption of other products, while buckwheat ferment, a fermented prebiotic, helps balance and nourish the skin's microbiome.
  • Microbiome Enzyme Essence
  • A bottle of True Botanicals Microbiome Enzyme Essence in a dark amber glass container with a black screw cap is displayed against a white background. Behind the bottle, two smooth droplets of golden, translucent liquid are spread, highlighting its lightweight and hydrating formula. The label emphasizes its placement in the "renew" collection.
  • Microbiome Enzyme Essence
  • Microbiome Enzyme Essence benefits highlighted on a soft bubbly background.
  • An image displaying "90% said their skin looks dewy after applying the product*" with before and after close-ups of the forehead, highlighting improvements after 4 weeks. A Microbiome Enzyme Essence bottle is featured alongside clinical study details.
  • 90% of participants said, "My skin feels baby soft." 93% reported, "My skin is healthier-looking." 90% said, "My skin looks dewy after using this product." *Based on a 28-day clinical study of 52 women aged 35-70 using the product twice daily.
  • An image showing "93% said their skin is healthier-looking*" with before and after close-ups of skin improvement after 4 weeks. A Microbiome Enzyme Essence bottle is featured, with study details below.
  • Pineapple and papaya enzymes help soften and exfoliate by shedding dead skin cells from the surface. Wild-sourced finger lime breaks down dead skin cells to enhance absorption of other products, while buckwheat ferment, a fermented prebiotic, helps balance and nourish the skin's microbiome.
  • Microbiome Enzyme Essence

Microbiome Enzyme Essence

$82

Clinically proven to deliver plump, dewy-looking skin, this next-generation essence is your skin’s daily prebiotic. Bioactive fruit enzymes gently resurface, while protecting, balancing, and strengthening the microbiome—like gut health, but for your skin.

Full Size (4oz | 118mL)
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Frequency Recommendation
We recommend the following replenishment cycle:
  • Usage
  • Frequency
  • Twice a day
  • Every 2 months
  • Once a day
  • Every 3 months
  • Just a few times a week
  • Every 4 months
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What It Is

Just like your gut, your skin depends on a thriving microbiome—an ecosystem of beneficial bacteria that protects, balances, and strengthens the skin barrier, and supports lasting hydration, smoothness, and resilience. Our Microbiome Enzyme Essence is formulated with active prebiotics to nourish that ecosystem, creating the optimal environment for healthy-looking, radiant skin. One of those prebiotics is fermented buckwheat, a nutrient-rich ingredient that helps good bacteria flourish while calming and balancing. Its soothing benefits make this essence especially comforting for dry, sensitive, or reactive skin.

Cellular turnover is essential to a healthy microbiome, but harsh acids and abrasive exfoliants can disrupt the skin barrier and do more harm than good. This formula uses gentle, non-irritating pineapple and papaya enzymes to dissolve dull, dead skin cells on the surface, along with wild-harvested finger lime—rich in naturally occurring AHAs—to smooth and brighten. The result is a baby-soft, even-toned complexion—dewy, plump, and it even diminishes the appearance of fine lines. This next-generation essence goes beyond a prep step in your daily routine. It strengthens, balances, and protects, building the foundation for long-term skin health and radiance.

This award-winning essence is dermatologist-tested, hypoallergenic, pregnancy-safe, microbiome-friendly, and MADE SAFE® certified.

Key Ingredients
  • pineapple ingredient

    Pineapple & Papaya Enzyme

  • fingerlime ingredient

    Wild-Sourced Finger Lime

  • buckweed ingredient

    Buckwheat Ferment

    Full Ingredients List

    camellia sinensis (green tea) leaf extract*, zingiber officinale (ginger) water*, aloe barbadensis leaf juice*, glycerin, maltodextrin, phenethyl alcohol, bromelain, papain, xanthan gum, ethylhexylglycerin, citrus australasica (finger lime) fruit extract, davidsonia jerseyana (davidson plum) fruit extract, sodium hyaluronate, sodium phytate, citric acid, water/aqua/eau, sodium benzoate, potassium sorbate.

    *organic

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      FAQs

      Can I use this with Clear Toner?

      Yes! After applying Clear Toner, you can apply our Microbiome Enzyme Essence. The two of them work better together!

      Is this good for all skin types?

      Yes, all skin types can benefit from the Microbiome Enzyme Essence, especially dry skin types. It’s also great for sensitive skin types!

      Is this product safe to use during pregnancy?

      Yes! Our Microbiome Enzyme Essence is MADE SAFE® Certified, which ensures it is free from over 15,000 known toxins and has undergone further rigorous testing to ensure it does not contain any ingredients known to or suspected of harming pregnant individuals. If you are pregnant or breastfeeding, we always recommend consulting with your doctor before introducing any new skincare products into your routine. Everyone's skin and situation is different, so we cannot take into account your unique needs that may contribute to differentiated standards during your pregnancy or postpartum period. For more information, check the MADE SAFE® Healthy Pregnancy Guide. 

      How long will the Microbiome Enzyme Essence last?

      Each bottle contains approximately 236 uses. When used twice daily, it will last about 118 days. If used once a day, it will last double the time - 236 days. Your usage may vary depending on how much you apply.

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      Made Safe logo
      PETA Approved logo
      EWG Verified
      Microbiome Friendly
      Learn More