• Microbiome Enzyme Essence from True Botanicals
  • Microbiome Enzyme Essence benefits highlighted on a soft bubbly background.
  • 90% of participants said, "My skin feels baby soft." 93% reported, "My skin is healthier-looking." 90% said, "My skin looks dewy after using this product." *Based on a 28-day clinical study of 52 women aged 35-70 using the product twice daily.
  • Pineapple and papaya enzymes help soften and exfoliate by shedding dead skin cells from the surface. Wild-sourced finger lime breaks down dead skin cells to enhance absorption of other products, while buckwheat ferment, a fermented prebiotic, helps balance and nourish the skin's microbiome.
  • True Botanicals Microbiome Enzyme Essence in an amber glass bottle, surrounded by golden liquid and soft, glowing orbs, highlighting a fluid, radiant texture.
  • Microbiome Enzyme Essence from True Botanicals
  • Microbiome Enzyme Essence benefits highlighted on a soft bubbly background.
  • 90% of participants said, "My skin feels baby soft." 93% reported, "My skin is healthier-looking." 90% said, "My skin looks dewy after using this product." *Based on a 28-day clinical study of 52 women aged 35-70 using the product twice daily.
  • Pineapple and papaya enzymes help soften and exfoliate by shedding dead skin cells from the surface. Wild-sourced finger lime breaks down dead skin cells to enhance absorption of other products, while buckwheat ferment, a fermented prebiotic, helps balance and nourish the skin's microbiome.
  • True Botanicals Microbiome Enzyme Essence in an amber glass bottle, surrounded by golden liquid and soft, glowing orbs, highlighting a fluid, radiant texture.

    Microbiome Enzyme Essence

    $82
    Size  
    Full Size (4oz | 118mL)
    • 20% off your first 3 orders
    • 15% off every order after
    • Free gift on your first 2 orders
    Frequency Recommendation
    We recommend the following replenishment cycle:
    • Usage
    • Frequency
    • Twice a day
    • Every 2 months
    • Once a day
    • Every 3 months
    • Just a few times a week
    • Every 4 months
    Free Shipping on orders $35+
    Try risk-free for 30 days or your money back

    Description

    Clinically proven to deliver plump, dewy-looking skin, this next-generation essence is your skin’s daily prebiotic. Bioactive fruit enzymes gently resurface, while protecting, balancing, and strengthening the microbiome—like gut health, but for your skin.

    How to Use

    After cleansing, pour 2-3 shakes in the palms of hands and gently press and pat into face and neck. Use in the morning and in the evening as needed.

    Ingredient List

    camellia sinensis (green tea) leaf extract*, zingiber officinale (ginger) water*, aloe barbadensis leaf juice*, glycerin, maltodextrin, phenethyl alcohol, bromelain, papain, xanthan gum, ethylhexylglycerin, citrus australasica (finger lime) fruit extract, davidsonia jerseyana (davidson plum) fruit extract, sodium hyaluronate, sodium phytate, citric acid, water/aqua/eau, sodium benzoate, potassium sorbate.

    Dermatologist Recommended

    "Cellular turnover is vital for youthful-looking skin, but it slows with age. This essence is exceptional because its micro-exfoliators promote cell turnover without disrupting the skin’s microbiome."

    Dr. Daniel Butler, MD, Board-Certified Dermatologist

      Clinical Results

      93%
      said their skin is healthier-looking*
      90%
      said their skin looks dewy after using this product*
      86%
      said their skin feels baby soft*

      *Based on a 28-day clinical study of 35 women aged 25-65, twice daily use

      • Pineapple & Papaya Enzyme

      • fingerlime ingredient

        Wild-Sourced Finger Lime

      • buckweed ingredient

        Buckwheat Ferment

        Beyond the Bottle

        Environmental Impact

        FAQs

        Can I use this with Clear Toner?

        Yes! After applying Clear Toner, you can apply our Microbiome Enzyme Essence. The two of them work better together!

        Is this good for all skin types?

        Yes, all skin types can benefit from the Microbiome Enzyme Essence, especially dry skin types. It’s also great for sensitive skin types!

        Is this product safe to use during pregnancy?

        Yes! Our Microbiome Enzyme Essence is MADE SAFE® Certified, which ensures it is free from over 15,000+ known toxins and has undergone further rigorous testing to ensure it does not contain any ingredients known to or suspected of harming pregnant individuals. For more information, check the MADE SAFE® Healthy Pregnancy Guide.

        We are also proud that this product has earned the Sorette Seal of Approval. That means the formulation has been vetted against Sorette’s No-Go List™, which restricts or prohibits ingredients connected to reproductive, developmental, or endocrine toxicity. The Seal indicates full ingredient disclosure and formulation transparency.

        If you are pregnant or breastfeeding, we always recommend consulting with your doctor before introducing any new skincare products into your routine. Everyone's skin and situation is different, so we cannot take into account your unique needs that may contribute to differentiated standards during your pregnancy or postpartum period.

        How long will the Microbiome Enzyme Essence last?

        Each bottle contains approximately 236 uses. When used twice daily, it will last about 118 days. If used once a day, it will last double the time - 236 days. Your usage may vary depending on how much you apply.

        Other Products You’ll Love

        • Bestseller
          100%
          saw a reduction in the look of fine lines and wrinkles
          True Botanicals Renew Pure Radiance Oil in a deep amber glass dropper bottle with a black rubber bulb top and gold logo, shown on a transparent background with a New You Beauty Awards 2022 Winner badge.

          Renew Pure Radiance Oil

          Renew Pure Radiance Oil

          Our best-selling face oil that helps target signs of aging and is clinically proven to outperform a leading anti-aging moisturizer.
        • Bestseller
          100%
          saw softer and smoother skin after 1 week
          True Botanicals Renew Chebula Active Serum in a deep amber glass dropper bottle with a black rubber bulb top and gold logo, shown on a transparent background with an InStyle 2025 Beauty Editors' Pick badge.

          Chebula Active Serum

          Chebula Active Serum

          This serum is clinically proven to outperform two leading anti-aging serums in fighting fine lines and wrinkles.
        • Bestseller
          100%
          saw a highly significant improvement in skin hydration
          True Botanicals cream jar on a beige background with ELLE Beauty Icon 2023 award badge.

          Phyto-Retinol Advanced Clinical Cream

          Phyto-Retinol Advanced Clinical Cream

          10 age-defying benefits in 1 cream. A retinol alternative for radiant, plump skin.
        • 112%
          increase in hydration around the eye area
          True Botanicals Resurrection Radiance Eye Cream jar on a white background

          Resurrection Radiance Eye Cream

          Resurrection Radiance Eye Cream

          Clinically proven to dramatically reduce the appearance of dark circles, puffiness and wrinkles around the eyes.